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| 1533 | First contact with Spaniards in Rio Yaqui Valley, Sonora, Mexico. |
| 1884 | Begin moving to Arizona. |
| 1890 | Old Guadalupe settled. |
| 1910 | Guadalupe settled on 40 acres. |
| 1960 | Yaquis in Old Pascua initiate request for land. |
| 1964 | Federal Government deeds 202.76 acres to "Pascua Yaqui Association". |
| 1978 | Federal recognition of the Tribe on September 18. |
| 1983 | Bingo Hall opens. |
| 1988 | Pascua Yaqui Constitution signed by Bureau of Indian Affairs. |
| 1994 | Yaquis given "Historic Status" under federal legislation. |
| 1994 | Gaming Compact with Arizona and Casino of the Sun opens. |
| 1995 | Pascua Yaqui Health Maintenance Organization established. |
| 2000 | First high-tech joint venture of a Native American tribe. |